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Let's say you're using the dirty trick combat maneuver. Let's say you have quick dirty trick, which says...
Benefit: On your turn, you can perform a single dirty trick combat maneuver in place of one of your melee attacks. You must choose the melee attack with the highest base attack bonus to make the dirty trick combat maneuver.
Normal: A dirty trick combat maneuver is a standard action.
and you're using it with a two-weapon fighter. Since you're not using the weapon for it, it's just straight CMB. do you take the -2 for two-weapon fighting if you give up your primary off-hand attack? how about a secondary natural weapon attack?