At the PaizoCon preview banquet, I was really struck by the idea that Paizo is branching out. Yeah, they're still supporting Pathfinder and Golarion with traditional products (their bread and butter), but they're also venturing into MMOs, VTTs, card games, and goblin dolls.
What I really, really want to see from Paizo though is a sci-fi RPG-- a game that could be to sci-fi what D&D and Pathfinder are to fantasy. It doesn't have to do all sub-genres of sci-fi, but it should create its own sub-genre, a smooth blend of cyberpunk, space opera, and hard sci-fi, with a hearty dash of post-apocalyptic sci-fi.
The core rulebook should give us pure-strain humans, modified humans/mutants, several species of aliens, and droids. It should give us classes that are as rich as the Pathfinder core classes, though maybe not quite that many: soldiers, diplomats, explorers, ESPers, etc... It should be fully supported with at least one adventure path (that should not take the place of the fantasy adventure path for any period of time at all). There should be an alien book (with lots of extra playable races).
It really could be grand. Come on, Paizo, do it. I dare you.