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I'm a bit confused about how afflictions work. I get that you first need to roll to see if you contract it -- if you save, you're fine. However, if you fail, say, the initial saving throw vs. poison, does it affect you immediately? Or is the first save "harmless" in the sense that you do not yet take any ability damage from it?
To illustrate this with a concrete example:
A fighter is poisoned with Greenblood Oil. He fails the saving throw, and contracts this affliction. Does he immediately take 1 point of con damage for failing this save, or not? Or does the effect (1 point of con damage per failed save) come into play when he fails the first "real" save after contracting the affliction?
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The first save is both to prevent damage and to negate the effect. If it fails, you take the damage and must make another save later.
Note however, that Poisons, Diseases, Curses, etc all work a bit differently. Generally, Poisons, have only two saves, while Curses mnight only have one and diseases have one infinitely until overcome. Diseases, also, do not take effect until after their incubation period, usually days later.