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I got the idea while perusing the "Is Second Darkness Setting Neutral" thread over in the Second Darkness forum, and I didn't want to disrupt that thread, so I made my own!
The more I think about it, the more Curse of the Crimson Throne works well in Eberron. I'm almost sorry I didn't think of this sooner--I'm in the middle of Seven Days to the Grave right now, waay too late to port my game over.
Let's drop Korvosa into Q'barra, the monarchist colony of Galifar over on the tropical eastern coast. This isolates it from a lot of the more pulp SF elements of the setting (no lightning rail, little airships). The desire to have ties to the monarchist past would allow for the ruler of a relatively small town like Korvosa calling themselves king or queen. And the area does have a history of people building pyramids--just swap out the Shoanti for lizardfolk.
The presence of dragonmarked houses, of relatively cheap low-level magic, makes running Seven Days to the Grave a little easier on the city... unless, of course, we make the Queen's Physicians halflings, members of House Jorasco, the House of Healing. It's been established that the nosomatic chiurgeons are a sect of House Jorasco that collects diseases and uses them to "cull the herd", as it were. And making the Physicians an established society (House Jorasco) makes them more trusted, and the twist of the second module all the more shocking.
Of course, human ethnicities are glossed over in Eberron. We would probably be best suited to replacing the Varisians with a non-human race. Shifters or changelings would do nicely as a persecuted minority.
As for Kazavon, I'm of two minds on how to treat him. The more by-the-book approach would be to use the original source more literally--Kazavon is a dragon servitor of one of the evil gods (the Mockery makes for a fantastic expy of Zon-Kuthon). The second, and the one I like more, would be to make him one of the Lords of Dust, an ancient rakshasa lord who took the form of a dragon as mockery of their enemies (similarly to how Dragons of Eberron treated Tiamat). This would help explain his undying nature, and tie him more thoroughly into the backstory of Eberron.
The one problem I see is that House Arkona are differently aligned rakshasas. Perhaps they follow a different patron amongst the Lords of Dust. Perhaps they're not rakshasas at all, but rather changelings and/or cultists of the Dragon Below.
A History of Ashes would require a lot of work to change around, especially following my previous model of "Shoanti = lizardfolk". All the desert flavor would have to be traded out for jungle, which is still, admittedly, a very hostile environment for those unprepared for its perils.
Scarwall could be set in either the Talenta Plains or in Valenar, with halfing barbarians or militant elves subsituting for orcs.
Queen Ileosa's plan to use the blood of Korvosa to make her immortal can still work quite nicely. Rather than drawing on the resources of a runelord, she could have found the secrets of the Qalabrin, an ancient sect of vampire elves that inspired the Blood of Vol religion. The Blood of Vol could also be the cult, rather than Urgathoa, backing the Physicians in Seven Days to the Grave.
So. What do you think, sirs?