James Jacobs
Creative Director
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The kyuss worm mechanic does not use the disease mechanic, nor are the worms called a "disease" in the monster description despite the fact that remove disease can destroy them. Paladins should thus be just as susceptible to Kyuss worms as anyone else, although if they're high-enough level they can get rid of them easilly enough with their spells and powers.
Of course, if you want to house-rule paladins some immunity to Kyuss worms (and higher level monks, for that matter), that'd probably be cool since immunity to disease is such a weak ability anyway in the grand scheme of class abilities. It could probably stand for getting a bone tossed its way.
Creatures that are immune to Intelligence damage, on the other hand, are immune to Kyuss worms.