I can generally tell which card is which now in certain runs, right down to if it's the villain, a monster, an ally or even a blessing. It's a skill I picked up from my childhood of trying to be a magician and doing tons of card tricks. It's drove me and my friends nuts because I honestly can't help it. I've resorted to having to buy coloured sleeves for the entire set.
Expensive but I really enjoy this game but my perception is ruining it for me so it was my only option.