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For instance, a lesser bestial mutagen gives you a more savage aspect with greater muscle mass, granting you a +2 item bonus to Athletics checks and unarmed attack rolls and increasing the amount of damage die you roll for such attacks, but this new form is clumsy and lumbering, imparting a -1 penalty to Acrobatics, Stealth, and Thievery checks, as well as to AC and Reflex saves.
I would discourage Paizo developers from adding any abilities as modifier-complex as the above. (+2 to Athletics, +2 to unarmed attacks, +1 die size for unarmed attacks, -1 to Acrobatics, -1 to Stealth, -1 to Thievery, -1 to Armor Class, -1 to Reflex Saves)
Even in the age of digital pads and auto-calculating character sheets, keeping track of the modifiers from a couple of such spells/effects takes away from the game. Players get busy with math instead of being in the moment, and combat pauses while everyone makes sure they get it all sorted correctly. No thanks, keep it simple(r) please.