I've always wanted to run a campaign in the Grimjack comic book's city of Cynosure. The laws of nature change from block to block. Gods walk the streets or beg from the gutters. Demon possessed computers cast spells and open portals to the abyss at microprocessor speeds. Tons of political intrigue and backroom backstabbing. And then you get to the rough part of town - The Pit; the remnant of a sentient universe that committed suicide.
In short, fun for the whole family!
Remember, at Munden's Bar - NO TOURBOTS!
A small gatorlizard holds up a shaky hand and pleads, "Ciiiigs!"