I wrote a world where fire arms and alchemy are just being starting to be a thing, the bbeg is an alchemist who is making a horde of alchemical monsters and mutants for various reasons. That being said I have created a few alchemical dungeons and one of them is where he is trying to construct artificial humans, a dungeon which opens up a whole slew of quests and adventures. My players seem more focused on completing the main quest and helping 3 factions come together to start exploring an island that ties the country they are in to the one far to the west. I'm actually impressed with how well it's going considering none of us have played any game like this. In the first few sessions we lost a few party members, the most memorable of which was our wizard running out of spells and stepping over the unconscious paladin screaming you shall not pass, to which the bugbear had one reply.
But there are tons of secrets and factions they haven't touched on these characters that may come out in later campaigns in this world, who knows!