The missus treated me to an early Christmas present of a new Nook Color and it's dreamy.
I tested out its built-in pdf reader by loading up a Pathfinder book and it works nearly perfectly. I had no trouble transferring the file from my laptop to the Nook via the included USB cable. At full page the text is a little small, but I can zoom in to a comfortable size and the touchy-slidey screen makes it pretty smooth to just move the page down as I read each column. There are some challenges come map time, not only because it's a little extra work to fit the map into the now-zoomed page (I either have to glide around different sections of the map OR zoom back out again, look at the map, then zoom back in to read), but also because there's no easy way to flip back to the map as I read each room.
Aside from that extra complication, the only actual glitch I've found is that some of the sidebars are blackened out. I'm specifically reading Children of the Void (Second Darkness #2) and all the sidebars so far are illegible. The background image is reproduced in a sort of dark, negative image over which the black text is unreadable.
So there you go. I'd been doing some reading on eReaders recently and thought I'd return with a report of how mine's been treating me in the world of reading Paizo pdf products.