I've always been intrigued by the Macho Women with Guns setting. And now I have the Pathfinder books. I could convert MWWG to Pathfinder easily enough, but it seems that a more creative idea might be in order.
Suppose that after three thousand years of wandering the planes, Circe returns to Earth. By now, she's earned so many XP that she has god-like powers, especially with her scepter in her hand. Being an ultrafeminist, she uses her scepter to transform the men of the world to various creatures from the Pathfinder Bestiary, and then leads an invasion of other creatures of the Pathfinder Bestiary to take over the Earth. Other creatures from the Pathfinder Bestiary might be attracted to the chaos, including some of the good outer planar creatures.
So after a while Circe rules the world from her castle on Mt Olympus, although most nations are either in rebellion against her, at war with each other, or both. Invaders from other planes have established a few footholds in various places.
And I probably shouldn't forget the zany satirical humor.
I don't know if I'll ever do anything with this, but it seems to be a start.