Everbody *still* wants to post their review on how it's different from 3.5E like this is somehow news? :-) Move on already!
It's interesting that in many of the negative reviews so far a number of the things folks see as "negatives" I view as "<shrug>" or "great".
It's a streamlined version of DnD. They traded some simulation aspects for some streamlined rules and gameplay. Ok. That's what it is. If you get a group of folks together I bet you could still manage to have some fun with it, within the context it presents.
Play 3.5E! Play PFRPG! Play 4E! Drink some beer, eat some fritos, have fun with your friends.
I feel like I must comment that the first game of 4E I played with the core books incorporated a drinking game. By the time we fought the dragon at the end we were toasted. Therefore I can wholeheartedly recommend 4E.