If your setting is something like the modern day, run in PF1 - I think that's what you're implying? - then there's a question about how the PCs would get across Europe with a bunch of weapons. European police are much, much more upset about people (especially foreigners) carrying live weapons than the US, and that includes swords and stuff. Whatever means they're using to hide their weapons will probably provide material for a session or two when it's threatened. Even if they're all in a bag of holding then maybe there's a dead magic zone.
Presumably there's a reason why they'd cross all of Europe rather than catch a ship down through the Mediterranean or a plane over it. Stories of monsters they're checking out or rumours of ancient relics that might be useful. Or both. Monster stories could link to Lamashtu obviously. Perhaps there are lycanthropes spreading their curse (her gifts) and preparing to converge on Italy or Greece or wherever for a great rite where the prophet will be anointed. The lycanthropes might be anything from motorcycle gangs to members of a multi-level cosmetic marketing scheme, depending on what flavour you like to deal with.
it wasn't modern day adventure but you have provided exactly what i was searching, a season main storyline, you have provided me with the lycanthropy plot, thank you very much