First thing first I'm so glad paizo retconned/fixed Lirgen's appearance/ancestry in Lost Omens. I do think Keftiu's point bears repeating in this book about "fantasy Sub-Saharan Africa" there are 10 cities detailed, four of those cities are run by "Black" natives. You have Senghor beingnrun by an Caldaru oligarchy, that unfortunate idea of Jaha, Bloodcove being an Aspis puppet, and even with Kibwe the book states that it was "Born from a conglomeration of indigenous tribes and foreigners." This makes Kibwe sound like it wouldn't have been possible without the divine intervention of colonizers. Hell the three cities left that are native run (Osibu, Mzali, and Nantambu) are cities that run on magic. This gives the impression that in this world the only way for these natives to have a "civilized" city is through magical miracles. Don't even get me started on Mzali.
I get it though it's very apparent in the way the book is written in certain parts that the exploitation of the Expanse and it's people is evil. That this exploitation is wrong and harmful to the natives who live there. The beginning of the Bloodcove entry for example. It's just hard to reconcile that idea that exploitation is bad when two of the adventure types for PCs are colonizer and missionaries. Honestly i don't think the writing is particularly insensitive, but I do think some of the world building/lore is. There are just things in the lore/ world building that are problematic that ultimately, no matter how sensitive your writing, do the writing no favors.
Mod note 7/8/21: the author of this post noted some additional context for their post a few comments down.