Thanks for the responses. In regard to the website referred by DMFTodd, a search reveals only four adventures for high level characters, two of which are for 20-21st level published in Dungeon. This in my opinion is an inadequate number of adventures to draw upon given that 20th level is the beginning of a new phase for many characters to perhaps go on to become deities. I disagree with the last comment that ultra high level adventures are more difficult to create...if one looks at the EPIC level handbook the sample adventure in there, the authors just provided hit points of CR20+ creatures and requires DMs to refer to the appropriate monster manual.
What would be great are more statistics for CR20+ creatures. The Book of Vile Deeds provides statistics of Demon Lords and rulers of Hell, which would provide great adventuring ideas.
Any further references from licenced publishers would be appreciated. Thanks in advance.