I'm pretty new to Lovecraft and Lovecraftian horror, but after purchasing Call of Cthulhu D20 on a whim, I proceeded to go out and buy just about every story I could find. Noting the obvious connection, I also went back to reread and replay every reference to the Far realm I could get my hands on. I am so happy to see this cross genre theme appear again and again, and Styes really put the icing on the cake.
I would trade my left arm to see an epic campain with a final battle against a Great Old One (Monte Cook, you out there?). I'm aware that a victory in this case would be very un-Lovecraftian, but fun as can be nonetheless.