R00kie's page

Take your pick:

Pathfinder Nexus
https://app.demiplane.com/nexus/pathfinder2e

Pathbuilder
https://pathbuilder2e.com/

HeroLab
https://www.wolflair.com/hlo/

Wanderer's Guide
https://wanderersguide.app/

Personally I'd recommend Pathbuilder today, but I suspect Pathfinder Nexus will become my go to once they work out the bugs. I've preordered Player Core, GM Core and Rage of Elements in Nexus.

I'm currently running an Iron Heroes / Savage Tides campaign.

The biggest problem is healing long term dibilitating effects. You'll need to introduce herbal remedies that cure everything from Petrification, to Zombifying diseases, and make sure they are generally available.

Appart from that I've encountered no problems (or no significant problems) fo far. The players are only mid way through the "Sea Wyvern's Wake", so there is the potential for trouble ahead.