I think it could be interesting to think up how certain combos of curse/mystery might interact to create unique experiences.
Flame/wasted: you where severly burned when you were young, over ninity percent of your body, but it did not cripple you, even when the burns became permantly infected, despite the best efforts of clerics. Some of the origional heat seems to have staid to, burning away any disease that seeks to infect you, aside from your infected burns.
Stone/Lame: When you were wondering forest, you accidently caught the gaze of a traveling medusa. When a local wizard found you later and cast stone to flesh on you, something went wrong, one of your legs got stuck a state half way between flesh and stone. It does not move the way it used to, but like stone it never gets tired.
Life/wasted: Positive engery seeps from so much that normally harmless orgasmism that dwell on your skin have grown out of control, giving you a hideous appearence. And negative effects of these diseases are healed by that same abundence of life engery. These diseases are not contagious as they die instantly without your nurturing presence.
Heavens/Haunted: At first you thought you were haunted by ghosts and called in experts to do an exorism, to no aviale. Then you started to catch glimpses of your tormenters out of the corner of your eyes. These spirits were no ghosts, but after seeing them, you wish they were. Anything but the mind twisting horrors from between the stars that they are, the things that seemed to enter this world through your dreams. In time, as you felt you sanity slipping away, you asked them why they were doing this to you. It was only then that they started whispering they're secrets to you.
Fire/Cloudly vision- You had a vision so powerful that it litterly burned the eyes right out of there sockets. Now flames burn in there place, like the eyes of a lich, offer you sights beyond anything you could imagine, but the smoke from them obscures your vision.
Bones/Death- You were having a piniac with your one true love, when a packs of gnolls attacked. She took hours to died, her screams endly. As the gnolls left you bleeding on the ground, but not dying as they assumed, her screams were the last thing you heard before falling unconious. They've been the only things you hear, endlessly, ever since.
Fire/Haunted- You thought it would be fun to visit that old abbandoned mansion down the street, reputed to have been a temple to Asmodeaus in times past, and haunted by by the cultists and its victims. You never believed those silly old stories. When you entered it was fine at first, but then strange things started occurs, objects moving of thier own accord, screams of pain from no wear, and moans of depraved pleasure, of someone enjoying unwilling flesh from empty bedrooms. In your haste to flee you dropped your torch and barely escaped the burning mansion with your life. With the mansion gone to ash you though it was over, you were safe now. Until the busty bar maid at your local tavern slapped you across the face accusing you of pincing her buttom, something you did not do. Or when her bounice come undone when servicing you later, all on it own, revealing a great deal of cleavage. But you knew something was wrong when the heat of your lust kept grewing, burning brighter inside of you then ever, before until you felt like you were going to burst, and the waves of heat exploded from you along with dark visions of you doing unspeakable thinks to the bar maid. Then the visions passed luckly you found you were able to heal her burns without scars, but saddly that's when the voices of the damned began speaking to you, in voices that crackle like flames.
Bones/cloudly vision- You got caught by a necromancer looking for expiremental subjects. He wanted to see what would happen if using unspeakable spells, he transplanted the eyes from one of his zombies into the head of a living person, you. The surgery was excuiting, nothing of course to help with pain. It was a success. You even regain partial normal senses and the necrotic engery in the eyes even allowed you to see in the dark. It turned out to be too much of a success, for you ended up with a connection to the mystery of bones itself, and the power to turn the tables on the necromancer himself. He learned alot more about undeath that day then he planned...
maybe I think of more latter and some thoughts on combos that are mechanicly good too, like lame with nature. so what do you guys think?