So this started with a thought: if I were running NPCs, assuming the PCs include one melee fighter who's obsessed with charging, what can I do that's neither A. focus firing the melee PC until they fall down every fight or B. being ineffective of the sake of being ineffective. So I arrived at C. apply crowd control to the melee fighter with some frequency, to justify NPCs shooting over their shoulder at the rest of the party.
Entangled seems like a good one. Moving at half speed, with charging prohibited and some -2s, means they may be able to limp over to an enemy and attack, or shake it off as a move action and have a standard to work with: it seems like a nice, interactive condition. It also imposes a penalty to Reflex saves, so I figured, hey, what else can I inflict out of a grenade?
Without further ado, the text for Blinded:
"You’re flat-footed, you take a –4 penalty to most Str– and Dex-based skill checks and opposed Perception checks, you automatically fail Perception checks based on sight, opponents have total concealment against you, and you must succeed at a DC 10 Acrobatics check to move faster than half speed or else fall prone."
So... flat-footed is a penalty to AC... Reflex saves are not a skill check, and have no requirement to see the attack coming or be able to move... do you mean to tell me a blind person can dodge grenades just as well as someone who can see?