| GreenThumb |
Just for some idea inspiration. In my current campaign the DM created a unique ability for my alchemist. I can derive a one hit wonder sort of poison from the essence of a body. The process of which causes sensory harm to my character. When I collect the poison he rolls a to see which of the five senses is the affected, then rolls again to see the effect.
My character has lost taste and smell for similar durations of 10 - 15 minutes. However over time the frequent use of this leads to chronic disruptions, which could be but not limited from complete loss of an entire sense. I had an interaction with an NPC who taught me this ability and he lost his sight from doing this too much.
I think unique handicaps are definitely welcome. The more hindrances your character has the better you feel when overcoming adversity. Forget trying to meta game. Go play Grand Theft Auto if you want a power trip RPG.