I'm late to the discussion but I have always wanted to run/play in a New World type game.
New World PC's are part of an expedition to a new continent. They start at a newly built fort and can go exploring from there.
Types of encounters/challenges - Natives (if PF this could mean anything from catfolk to nagaji), dwindling supplies, rampaging beasts, other expeditions, ruins, storms, and so on.
Liking the little I have read so far on this board btw.
Happy Gaming All,
HM