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I wouldn't allow the syringe to overcome DR unless it possessed the proper material/enchantment/alignment combo, and I'd make it a melee touch attack that provokes an attack of opportunity. One could also use it in a grapple, making for some pretty intense moments. The whole thing would look pretty cinematic.N'Wah, I think that making the delivery a melee touch attack that provokes an AoO is a good call. The cinematic possibilities are definitely fun. I don't think that a syringe itself would do more than 1 point of damage...unless you really tried to make the injection hurt with violent movement or something (which is where the +Str might come in). After all, syringe's are supposed to be designed to cause as little physical damage as possible, aren't they? And we're talking about a very thin, weak tube of metal, so being overly forceful will risk bending the needle and making it practically useless for delivering the potion.
I was a medic in the Navy and one thing I learned is that a needle can cause a lot of tissue dmg. Not hurting the patiant is about techniqe and if you do it wrong you could tear a muscle or bust a vein (this has happenes when a person is thrashing around and won't cooperate). A needle is still a long pointed object and if you stick the right spot you could seriously injure or kill someone. Also, only recently have needles become smaller and people friendly so I would guess in a less advanced setting the needles would be longer and thicker than what is availible. Besides if you look at the illustration of Filge you can see that he has a good sized needle and syringe. Many people would start whimpering just looking at that thing coming at them. Just to illustrate a point, I have witnessed "big bad-ass marines" faint at the sight of a cm long needle.