yellowdingo
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Black Death
Epidemiological studies suggest the disease was transferred between humans (which happens rarely with Yersinia pestis and very rarely for Bacillus anthracis), and some genes that determine immunity to Ebola-like viruses are much more widespread in Europe than in other parts of the world. Their research and findings are thoroughly documented in Biology of Plagues. More recently the researchers have published computer modeling demonstrating how the Black Death has made around 10% of Europeans resistant to HIV.-Wiki
So this virus came out of Africa, not Asia? And it was spread through human to human contact as opposed to fleas on rats? There would need to be signs of an ebola source 'Black Death' having originated in Africa and/or a resistance spike in the indigenous population. But if it emerged in Europe then the Resistance spike would only exist in europeans.
Genetic Resistance: Here was the mutation showing up again in the population...Areas of Europe that had been affected by the plague (including America, which was mostly settled by European plague survivors and their descendents) also had unusually high levels of CCR5-delta 32 — about fourteen per cent of the population compared to two percent in areas that never experienced the Black Death — such as Asia and Africa.
With a spread rate of 2 miles per day (that would be one eight mile hex per week in D&D map terms).