The release of 5e has shown some good advancements, but come on guys... Paizo already shown that can do much better than that.
The 5e, besides some good improvements and reverting back to 2E in many good ways, it has basically abandoned all the progress made with 3.0, 3.5 and 4E.
I think there is a good window of opportunity for Paizo to start planning a version of Pathfinder II. This could keep Pathfinder I own advances but also give some direction to the advances made with 4e (condensed skills, combat advantage), 5e (itterative attacks as standard action) and beyond.
For example, 5e has thrown away the mechanic that gave weapons different critical threat ranges and multipliers, a mechanic that used to help to each weapon to become more unic.
As a suggestion for Pathfinder 2, I would start to tinker with a defense bonus for all classes and monsters scaling at a rate of one-half the character's Base Attack Bonus. This would help to reduce the system dependence to magical itens for those like me that play in low magic settings. If you choose to use a Base Defense Bonus (BDB) you should also think about dropping BAB decreasing progression of +20/+15/+10/+5, and make all itterative attack the same BAB, or maybe a faster scaling for the second and third itterative attack so at later levels they can reach the first attack BAB.
These are just some ideas, but the message I would like to pass above all is that, THERE IS ROOM for a PATHFINDER II, if not now, in a near future, and we will be waiting for that!
Cheers.