This would be awesome. At the moment I'm having to make modifications to Wizards' d20 Modern/Future systems for a homebrew campaign to bring them in line with the 3.75 rules, but I'm seriously considering building a Mass Effect-based campaign in the near future. The idea of transcribing all of the Codex entries for a player guide is rather daunting though, and converting the classes might be a little odd.
Perhaps this is a good time for someone at Paizo to see if Bioware might be interested in tabletop versions of Mass Effect and Dragon Age campaign settings.
Speaking of which - I'm tweaking a conversion of the Wheel of Time RPG to 3.75 as well. This has been a little awkward because of some of the mechanics changes made for the Wheel of Time's low magic setting but has gone fairly smoothly. What are the odds that Paizo could pick this up as well?