I think my favorite thing about Golarion is how much fun it is to play around with. It feels like a massive box of crayons with more colors than I could ever possibly need, but it's super easy to just grab a handful of them and go nuts.
One thing that I've been doing a lot of lately is making up magical/alchemical cocktails to add a little zest to my players' (many, many) bar crawls, so they have some minor mechanical toys to play with while also getting drip fed setting detail. For example, they're currently causing chaos inside a casino in Vyre, so I made them a drinking menu, taking thematic inspiration from Vyre/Ravounel's culture and various PF2e mutagens. They don't have any levels or traits as they're intended to be goofy one-offs, so I don't consider these publication-ready or anything, lol.
The Blackfinger: A shot of deep blue liquid with a drop of inky, black something roiling within. Said to contain the venom of a scorpion sacred to the god of thieves, assassins, and spies, it sharpens the mind, yet weakens the body. Thick and fruity with a smoky aftertase. You gain a +2 status bonus to intelligence- and wisdom-based skill checks for one hour, but are drained 2 for the duration.
Rhom-Razzle-Dazzle: Gnomish honeycap mushroom wine that fizzes and sparkles, with a warm and buttery flavor that tickles on the way down. Imbues the drinker with good luck, but dangerously emboldens them. You instantly gain a Hero Point, but you must pass a will save equal to your class DC to refuse any wager for the next hour.
Silver Raven: Consisting of good, clear vodka with ice and crushed herbs, this simple cocktail is light, botanical, and refreshing. Taking its name from the freedom fighters who helped liberate Ravounel from Chellish rule, it similarly frees the drinker from whatever else they've recently put in their stomachs. Any magical or alchemical effects from other imbibed substances instantly end, and you gain one stage of alcohol poisoning (GMG pg. 120) with no saving throw.
What kind of minor homebrew--be it small details, one-off gameplay mechanics, or little plot/character beats--has Golarion inspired in your own games? I figure I'm not the only one who loves making stuff like this, and wanted to see what everyone else is up to. I've lurked keftiu's threads about regional adventuring parties, and while those are pretty boss, I wanted a space for the little stuff.