When you are attacking someone who has been turned to stone by the Medusa Mask
"The subject, along with all its carried gear, turns into a mindless, inert statue. If the statue resulting from this spell is broken or damaged, the subject (if ever returned to its original state) has similar damage or deformities. The creature is not dead, but it does not seem to be alive either when viewed with spells such as deathwatch.
Only creatures made of flesh are affected by this spell."
Do you roll vs their AC and their HPs or do you have to work out the conversion of them into the Material Stone?
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I would treat them as an object.
Being made of stone gives you Hardness 8 and 10hp per inch of thickness.
How that relates to someone when they "wake up" would likely be GM fiat, but if you have enough time to chisel out their internal organs you should be able to kill them.