One of my favorite 'independent' graphic novels is Top Cow's Madame Mirage. They only did the one story as a full compilation but I found it wonderfully imaginative, beautifully drawn (and especially colored) and very clever in its story-telling and reveal. It even had a little self-parody thrown in for good measure.
For those of you who haven't read it, its highly recommended. For those of you who have, how would you cast it? A younger Monica Bellucci would have been a good fit physically, I imagine, though I don't see her being quite... vivacious... enough to pull off the lead. And for the younger sister, my first thought was Amanda Seyfried, but I don't think she'd be able to manage the pathos necessary. Usually I'm pretty good at this, but this one kind of has me stumped - which is ironic, given how archetypical these characters are, at least on the surface. Thoughts?