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So, let's say a 2nd level Paladin, or a 4th level Monk, catches a Disease of some sort.
Let's say it's not fatal.
Let's further assume they adventure on and make a level each. Now they are both immune to diseases, so they can't catch any new ones.
What happens to the ones they had? Are they grandfathered in?
No. They are immune. Accumulated damage still remains