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Wow! I didn't expect this many responses!
Thank you Rysky for the previous thread link! Thank you, both James and Mark, for responding. I'm super excited for the release of the core game and for the upcoming GMG! Gladdened to hear there will be a chapter on how to change stuff like Alignment. Can't wait to read the whole book!
Despite the modular nature of PF2, I'm always somewhat hesitant to remove or adjust mechanics that touch on such a wide breadth of the game. Too afraid to break everything. That's why it's nice to see official suggestions on how to adjust it from people who have a much deeper understanding of the system than myself.
As for the rest of the thread- My short answer is: I save myself from having any of these alignment arguments by removing it entirely in the vast majority of my games. I most often use a home-brew setting. If alignment is too integrated into a system be easily removed, I try to adjust all the words away from moral and ethical concepts.