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And heck, you can still toss Mythic onto it (at least theoretically) and have E6/7/8 characters taking on mid-teens CR challenges.
Funny you should mention Mythic - I am doing almost exactly that for my homebrew campaign: E12 with up to 6 Mythic Tiers.
I've gone into the reasons elsewhere, but level 6-12 is the "sweet spot" for me, both as a player and as a GM. Traditionally, campaigns peter out around level 12 or 13 as that's where the characters want to settle down and run temples/guilds/small countries (several of them are still around as NPCs).
12th level is also the point where the progressions converge - your BAB goes up whatever progression you're on, Good Saves hit 8, Poor Saves hit 4, and you get your 3rd ability increase. This was even more true in 3.X where you got feats at every third level instead of every odd level. If you didn't know better, you could look at the charts and think they were *MEANT* to run out of 12 the way everything progresses in multiples of 2, 3, or 4.
Capping class advancement at 12 but allowing mythic tiers means that I can still use most if not all of the Bestiary Monsters without excessive tweaking. There is a theoretical maximum of 224 HP without magic (assuming a pure Barbarian with 22 CON, Toughness, and a loaded d12) which is manageable - in reality most PCs will struggle to get into triple figures. You also qualify for most feats by then - which is even more important in E(X).
Besides, Antimagic Field/Raise Dead/Teleport/Polymorph is about as high magic as I like to go - if you want a Wish, go out and convince a Genie to grant it to you...
Which is great for my game in my setting with my players.
Other groups may prefer E6, or E8, or the full 20 level progression - or indeed E1, which definitely sounds like an interesting way of converting D20 to a skill based system for those who feel so inclined.
One of the things I love about Pathfinder/D20 is that it is so adaptable, and you can use it as a toolkit to play in all these styles if you wish. Embrace the diversity people!