Sorry to hear you won't be there, but hope everything goes wonderfully with the addition to the family. No pressure, but we expect he/she to be writing fabulous content by 2029!
As for advice for newbie PaizoCon attendees, I would say, just "run up to it and hug it!".
I live in England, and last year I went to the UK version of PaizoCon for my first encounter with the Pathfinder Society.
I cannot speak highly enough of the exceptional efforts of the people who organised the event, the fabulous GM's who made every adventure an UTTER joy, and how good it was to meet new faces who love gaming as much as I do. And from what I hear the US PaizoCon is even better!
The tradition of having a "meet up for a great meal the night before the convention actually starts" is inspired, and sets the tone for the entire weekend. You'll be gaming with friends, it's just that you may not have met them yet.
For me, this will be my first time at a US games convention. Given the airfare, it boiled down to choosing this or GenCon. Between the two, only one had "Paizo" in the title, so it was a simple decision.
I predict the "best thing about the weekend" will be something you didn't plan and would never have thought of.
Or possibly, "Lilith's cookies". From what I hear, they're worth the airfare alone!