|moon glum RPG Superstar 2015 Top 8|
There are already many pathfinder monsters that work in a high tech star-faring setting-- especially the Lovecraftian monsters, oozes and plants.
Monsters that can fight starships would be cool.
From classic trek, I'd like to see the extra-dimensional alien sorcerer space chickens from 'Cat's Paw'.
Inspired by Cordwainer Smith: wormhole dwelling phase dragons, and genetically modified human/animal creatures.
I expect that the krytons and the various creatures from the dominion of the black will be present.
Organic spaceships that have gone rogue, super sentient fungi that take over asteroids mining colonies and end up creating mossy mimicries of the humans and structures in the colony, undead planets, nebula oozes.