I'm sure there are some published adventures out there that would suit you, but all I can offer is what we did.
When the PC's went through Thistletop they had Shalelu with them. Bruthazmus had been set up as her nemesis earlier on and he managed to escape during the confusion of the final battle, with Shalelu in hot pursuit. The PC's later had to track down Bruthazmus to his new lair and rescue the captured Shalelu... it was actually pretty intense - he had taken over a small bugbear tribe with the assistance of an Ettin thug. He had her staked out to a post and was using her for target practice, having the tribal shaman heal her periodically; she had even been healed around a couple of arrows that had her pinned to the post... the PC's had developed a positive relationship with her early on and this really drove home to them Bruthazmus' villainy.
Another thing that happened before we got to Skinsaw - the PC's hadn't cleared out Thistletop, they had failed to find the secret doors down to the Giant Hermit Crab or to Malfeshnekor's prison. They had also avoided the Bunyip and the Tentamort, thanks in part to Orik's switching sides. So I had two druids show up in town, a Dwarf and a Half-elf run like a sort of odd couple... they had designs on inhabiting Thistletop themselves, but sought the PC's aid in removing the 'evil they still sensed within its depths'. I added an encounter with some Harpies whom had taken the topmost part as their lair and the return to Thistletop became a full-fledged adventure all on its own.
Not sure if any of that helps but there it is. I also wrote up an encounter where the PC's had to guard a shipment of mithril from a Dwarven mining community to Magnimar in return for having some of it worked into chain shirts and a breastplate for the martials. One of the guards was actually a member of the local bandit group whom had set an ambush (bandit leader was a Ranger with an eagle animal companion and his second was a Sorcerer, the rest were 1st level Fighter/1st level Rogues). Having a traitor in their midst proved a challenge when he grappled the party Wizard as soon as the fight began.