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The White Wolf World of Darkness games, Vampire the Masquerade, Mage the Ascension, etc. often had 'splats' (such as the Akashic Brotherhood, Assamites, Black Furies, or Dreamspeakers) devoted to groups composed primarily by different ethnicities or groupings in the setting, or even entire sub-games (Kindred of the East, Mummy).
Aeon/Trinity concentrated on a future setting where the dominant cultures were China and Brazil, with Europe and America being in decline (and Australia and the 'United African Nations' also being strong powers). Aberrant, less so, but still set the most relevant 'centers' of the game in places like Addis Ababa and Ibiza (unlike the comic books that inspired them, which seemed to set their 'Greenwich Mean Time' with the assumption that New York City/Metropolis are the center of the universe).