I'm running a group through Runelords via Fantasy Grounds and having a good time of it. I have four players who, as a whole are fairly experienced gamers, even though they may not have much experience with PFRPG.
We are working throug Skinsaw, and the timing worked out as such that they had a choice to either checkout the farms, or go to the Misgivings. They chose to go to the Misgivings as they felt that was more related to the murders (certainly), and let the sheriff send 4 guards and one acolyte of Desna to investigate the farms—not a big deal; the PCs are just going to have 5 more "friends" to deal with if they go there.
They enter the house through the Manticore room, go by the spiral stain (all but ignoring it—though extremely concerned about the monkey head), through the library, and then up. The thief triggers the worried wife, and tries to drag the wizard out. Moderately successful, they both end up outside, see the ravens and go back inside, triggering the burning manticore.
Then they split up. The thief and the cleric go upstairs. The barbarian starts kicking in every door she sees. The wizard gets choked by the scarf, drops to -1, but stabilizes, is found and the cleric and thief comes back down to revive him.
Later, the barbarian—again after the party is split up—CdGs herself with the twig (though I only dropped her to -1 instead of killing her). She is finally found before she fails all of her stabilize rolls.
They were at least together when they found Iesha, and made short work of her.
They are pretty much triggering the haunts individually, and if someone who isn't associated with the haunt walks into the room, the haunt doesn't go off (though I do have it trigger when the person eventually walks by—if they don't go into the room themselves).
The whisper function of the program lets me describe the effects to that character only, so it's pretty interesting to see how the others naturally react to the given situation. Though, because they're spreading out and triggering the haunts separately, they're not getting the story of the house as a group, they're each getting separate parts at different times, and since they each keep triggering haunts, they're not giving themselves any real time to put the pieces together. Though, they did pick up on the fact that the guy they saved from the goblins is associated somehow—the wizard did see him when getting choked by the scarf, but none have concluded that he was actively involved.
I think they're enjoying the house, or at the very least, taking things in stride. I just can't help but shake my head in wonder as they all go off and do their own things.
EDIT: the humorous thing for me is that they're convinced that everything is a trap of mechanical or magical nature—and chortle as they fail in their attempts to deal with these things in the "normal" way.