We're almost at the end of Book 4, but the standout moment of the campaign so far came all the way back in the second session:
The party had routed the goblins in their attack on the town, and in investigating the corpses of the attackers, they noticed that some of the goblin gear seemed to have been salvaged from the town's own garbage. Two characters, an irresponsible rogue and a dissolute and slightly mad ranger, got very drunk, failed to drink the hagfish water, and decided that the fact that the goblins were scavenging trash was a Highly Significant Clue. Therefore they wandered over to Junker's Edge and tried to climb down to inspect the dump.
The rogue made his roll with aplomb, despite the penalty for drunkenness, and made it to the ground.
The ranger, however, rolled a natural 1 for a total of about 5; he also made it to the ground, but only by means of losing his grasp on the cliff face, pinwheeling down the rocks, and landing in the surf at something like -6 hp. The rogue hauled him out of the surf but was faced with a rising tide that threatened to drown them both. I had the ranger's player make a d20 roll as a Luck Roll (thank you, Call of Cthulhu!) and he rolled a 1. Just as he was staring up the cliff, trying to figure out how to haul an unconscious 220-lb man up them, the Gorvi boys begin tossing the detritus of the previous day's celebration over the cliff...
The ranger's player is long gone from the campaign, but we who remain often look back in amusement. :-D