If everyone is new, LESS is MORE. Directly limit this campaign to the CRB and APG. But always be ready to lift that limit when you and your group are ready to expand.
IMO the Biggest Deal in playing with new players is PLAYING. You are right to be wary of Option Paralysis. But not just for them, but you, too. Play simple, and get a good feel for the basics. Sorta like learning to drive in a parking lot so you get a feel for the clutch and steering (what, no clutch?) then to streets, then to freeways.
The most important rule to remember is Rule ZERO. You are the GM, the referee, the rest of the world. Your word is final and the players must know this. This is a HUGE responsibility. Be fair and hones with players, never take things personally (unless it truly is), let the players be rock stars, make consistent rulings (make notes on how something was adjudicated if you need reminders!). Or, to rephrase it: The players have to trust you with Rule ZERO. Earn that trust-it is the hallmark of a good GM.
House Rules? Yours will come in time, you will see what your table needs to do to make the game more enjoyable for everyone. (I do like the idea of a bonus Profession Skill point!)
Good luck and may the dice be ever in your favor... or is that a bit biased to hope that for a GM?