|Chad Brown Pathfinder Adventure Card Game Developer|
I think my solo game will be a three-character run of Imrijka, Alain, and Enora. I did Kyra through Runelords and would prefer not to use her again, even though Imrijka's divine is weak (seems like you kind of need divine in this set - at least one). I'm tempted to pull in Tarlin; Blessing of Iomedae's in the mix.
That's a solid group, going with the splitting-up-specialties plan. I'd recommend that you give WotR Kyra a spin for a bit, though, and see what you think - she has a very different play-style than RotR Kyra. Shardra is also a good Divine option, if you need one.
And, of course, don't overlook Seelah.